Drug Delivery 

Cutting-edge innovation for improved drug delivery of a wide range of active ingredients.

We specialize in optimal formulations to achieve targeted release and exposure of medications.​

Innovation with the patient experience in mind

Our Focus

Selecting the most suitable dosage form is a critical strategy for optimizing physicochemical properties such as chemical and physical stability, solubility, dissolution rate, and bioavailability.

Our focus is on combining the right dose form with the optimal formulation to achieve targeted release and exposure of medications in the blood and organs, with a focus on oral pharmaceutical drug delivery.

Advantages

Our advanced drug delivery systems can address safety and efficacy limitations observed during clinical development of new molecular entities by improving their pharmacokinetic and pharmacodynamic profiles.

They can also offer drug developers new strategies for surviving patent cliffs by extending market exclusivity when the novel dose form addresses bona fide patient needs. For example, improved delivery systems can improve medication adherence and the patient experience by reducing dose frequency, side effects, and invasiveness.

INTRODUCING THE

CUREform Portfolio

CURE’s Novel Drug Delivery Platform Portfolio Includes:

Oral Thin Film
CUREfilm®

Chewables
CUREpods™

Topicals
CUREcream™

Oral Solution
CUREdrops™

CUREform Advantages 

Increased bioavailability
through greater water solubility, enhanced permeability and retention in target tissue.
Specific release profiles
allow for controlled time release of actives.
Better patient experience
with effective symptom relief, improved taste masking, and overall ease of use.
Protection from degradation

during manufacturing and throughout shelf life.

CUREfilm®

Our Flagship Technology

CUREfilm®

Our Flagship Technology

CUREfilm® delivers better solubility, bioavailability, and ease of use for a better consumer and patient experience

CUREfilm® is our oral thin film platform for optimizing the absorption and metabolism of therapeutic actives. Oral soluble film technology is a versatile dose form that allows us to create proprietary products with optimal release profiles for better patient outcomes and consumer experiences.

CUREfilm® Explained 

CUREfilm® Explained 

CUREfilm® products are about the size of a postage stamp and can deliver therapeutic actives through the oral mucosal tissue, sublingually or buccally – between the cheek and gum – or more traditionally via the gastrointestinal tract. Oral transmucosal drug delivery is a non-invasive route reserved for pharmaceutical drugs that allows for absorption directly into the vascularized tissue in the mouth, bypassing the hepatic first pass effect. This leads to reduced drug exposure and can offer a rapid onset of action.

Active ingredients in the CUREfilm® dose form can be either pre-solubilized within its matrix or encapsulated, or both for more effective absorption and/or sustained release. As oral thin films quickly dissolve, no water is required for their administration, improving patient compliance – especially among the elderly, children, and in conditions where patients have difficulty in swallowing.

CUREfilm® products are about the size of a postage stamp and can deliver therapeutic actives through the oral mucosal tissue, sublingually or buccally – between the cheek and gum – or more traditionally via the gastrointestinal tract. Oral transmucosal drug delivery is a non-invasive route reserved for pharmaceutical drugs that allows for absorption directly into the vascularized tissue in the mouth, bypassing the hepatic first pass effect. This leads to reduced drug exposure and can offer a rapid onset of action.

Active ingredients in the CUREfilm® dose form can be either pre-solubilized within its matrix or encapsulated, or both for more effective absorption and/or sustained release. As oral thin films quickly dissolve, no water is required for their administration, improving patient compliance – especially among the elderly, children, and in conditions where patients have difficulty in swallowing.

CUREfilm® Advantages

CUREfilm® Advantages

KEY ATTRIBUTES

  • Sublingual and buccal delivery options for direct absorption into the bloodstream, avoiding first-pass metabolism (pharmaceutical drugs only)
  • No need for water, swallowing, or chewing
  • Multiples actives can be loaded onto each film
  • Uniform drug distribution allows for precision dosing
  • Potential for faster onset, clinical effect, and symptom relief
  • Potential for reduced side effects with a lower dose

DOSE LOADING

  • Multiple actives up to 200mg
  • Stable at room temperature for most active ingredients

APPLICATIONS​

  • Suitable for both pharmaceuticals and wellness products (per oral only)

Chewables

CUREpods™
chewable technology

CUREpods™ overcome problems with poorly soluble and poorly absorbed nutrients, particularly when high doses are required

A novel chewable delivery system, CUREpods™, delivers encapsulated and stabilized active ingredients in liquid or solid form using a complex coacervation technique that combines water-soluble proteins, polysaccharides, carbohydrates, alginates and lipids.

Our CUREpods® chewable product is formed by the complexation of polymers stabilized by chemical crosslinking, and then cast and molded into a range of shapes and sizes.

The active ingredients can be formulated for release upon chewing, exposure to the digestive environment or both. Furthermore, distinct layers may be formed to deliver multiple active ingredients in the same dose unit, with distinct release profiles if needed. Their texture and consistency are designed to be organoleptically pleasing for improved patient adherence while balancing child safety risks.

The mouth feel, dissolution time, and release of active ingredients from a CUREpod™ can be modulated by altering the excipient ratios.

CUREpods™ Advantages

CUREpods™ Advantages

KEY ATTRIBUTES

  • Simultaneously load fat soluble and water soluble molecules
  • Overcomes problems with poorly soluble and poorly absorbed nutrients
  • Multiple shapes, sizes, flavors, and colors

DOSE LOADING

  • High doses of actives (grams)

APPLICATIONS​

  • Ideal for sports wellness products

Topicals

CUREcream™

CUREcream™ is an elegant cream formulation that delivers greater absorption, stability and efficacy

The targeting of active molecules to specific layers of the skin requires advanced dermal drug delivery systems. We develop shelf-stable topical formulations that stay at the surface of the skin or penetrate beneath the skin depending on the desired benefit.

CUREcream™ Explained 

CUREcream™ Explained 

Using pharmaceutical industry-standard in vitro assays, our CUREcreams can be formulated for superior or faster flow into the dermis. Based on our in vitro studies, we’ve achieved 100-fold increase in overall dermal or transdermal permeation of cannabidiol (CBD) at equivalent concentrations compared to commercial reference formulations. We tailor to desired permeation kinetics by modifying process order and encapsulation methods.

KEY ATTRIBUTES

  • Suitable for consumer and pharmaceutical products
  • We offer formulation development services only

Oral Solution

CUREdrops™

CUREdrops™ water-based formulas offer a more pleasant mouthfeel over traditional oil-based tinctures

Our water-based formulas stabilize oil-based and water soluble ingredients, alone or in combination, for a better mouthfeel and increased bioavailability.

CUREdrops™ Explained 

CUREdrops™ Explained

CUREdrop™ solutions are best applied to uniformly incorporate fat soluble active ingredients into water-based liquids. This is accomplished using various micro-emulsification techniques which can be designed to improve stability as well as bioavailability. CUREdrops™ can be diluted (e.g. beverage) or concentrated (e.g. tincture). This dose form is adequate for consumer products as well pharmaceuticals which can be administered sublingually.

 

Based on in vitro assays, CUREdrops™ formulated for delivering cannabidiol (CBD) exhibit up to 500x greater permeation than commercial CBD soft gels and CBD in MCT oil at the same dose.

CUREdrops™ Advantages

CUREdrops™ Advantages

KEY ATTRIBUTES

  • Create homogenous water-based solutions delivering fat-soluble active ingredients
  • Sublingual options for direct absorption into the bloodstream, avoiding first-pass metabolism (drugs only)
  • Potential for faster onset, clinical effect and symptom relief
  • Potential for reduced side effects with a lower dos

DOSE LOADING

  • Multiple actives up to 100mg/ml of encapsulated active ingredient(s)
  • Stable at room temperature for most molecules

APPLICATIONS​

  • Suitable for both pharmaceuticals and consumer wellness products