Although medications are effective in combating disease, their full benefits are often not realized because approximately 40% of patients do not take their medications as prescribed.
For some, the experience of taking pills is unpleasant. It can be difficult or painful, which leads to poor medication adherence. In addition, the experience of taking pills can further irritate the GI tract causing diarrhea, constipation, cramps and dyspepsia. When swallowed, pills need to be dissolved by the body into small enough particles to be absorbed. During this process, as much as 80% of the drug may get metabolized by the liver and excreted.
While liquids can be offered as an alternative delivery method, they often taste terrible and can be challenging to administer to children and pets. As far as injections go, most patients strongly dislike the experience, particularly when self-administered.
In order for drugs to work, three factors must be carefully balanced: efficacy, safety and adherence. However, oral drug delivery is an inefficient process, involving many factors including individual patient circumstances that can lead to poor adherence.
Alternative oral routes of delivery can positively impact drug efficacy, safety and the patient experience. In fact, sublingual delivery (under the tongue) and buccal delivery (between cheek and gum) are proven to lead to direct absorption into the bloodstream and avoid:
CUREfilm® is our platform for optimizing and delivering drugs. Our oral soluble film technology is a versatile formulation platform that allows us to create proprietary drug products with optimal release profiles for better patient outcomes and experiences. Our formulations can be used in multiple final dosage forms based on the desired drug release profile and user experience.
CURE’s proprietary oral dissolving film technology unleashes the full potential of drug treatments. Our technology can improve the efficacy and safety of new and existing drugs, match or improve pharmacokinetic drug profiles, and stabilize plasma levels over extended time periods, possibly reducing dose frequency and side effects.
With CURE’s technology, drugs can be delivered to bypass the GI tract, avoiding GI side effects and inactivation in the gut and liver. Our nanoencapsulation methods protect the active ingredient from degradation in the biological environment, prolong the drug’s presence in the blood and increase cellular uptake.
With CURE’s technology, high drug loads can be achieved, clearing the way to deliver many classes of molecules, targeting a range of indications.