The seminal paper on the “entourage effect” describes how the ‘entourage effect’ may represent a novel route for molecular regulation of endogenous cannabinoid activity.

Ben-Shabat, Shimon & Fride, Ester & Sheskin, Tzviel & Tamiri, Tsippy & Rhee, Man & Vogel, Zvi & Bisogno, Tiziana & De petrocellis, Luciano & Di Marzo, Vincenzo & Mechoulam, Raphael. (1998). An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. European Journal of Pharmacology. 353. 23-31. 10.1016/S0014-2999(98)00392-6.

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